Levetiracetam-associated aggravation of myoclonic seizure in children

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Levetiracetam-associated aggravation of myoclonic seizure in children

Some antiepileptic drugs (AEDs) have been reported to aggravate generalized seizures. We have seen three children whose myoclonic seizures increased on starting treatment with Levetiracetam. In all seizures aggravation was temporally associated to the introduction of the drug. All became seizure-free on withdrawal of levetiracetam with a switch to an alternative antiepileptic drug and this pers...

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Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies.

We present a patient with cryptogenic focal epilepsy and another with Dravet syndrome, who experienced seizure aggravation and negative myoclonus, associated with continuous spikes and waves during slow sleep, induced by levetiracetam. For both patients levetiracetam was discontinued, and there was significant improvement of this particular electroclinical picture.

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comparison of levetiracetam with sodium valproate in controlling seizure in patients suffering from juvenile myoclonic epilepsy

conclusions it became clear at the end of the study that the effectiveness of two drugs were the same and they didn’t have any meaningful difference. according to the result gained from this study, levetiracetam is a proper alternative treatment instead of sodium valproate which has appropriate effectiveness along with lower complications. results comparison of mean generalized tonic colonic at...

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Levetiracetam monotherapy in juvenile myoclonic epilepsy

PURPOSE To describe our experience with levetiracetam (LEV) as initial or conversion monotherapy treatment for juvenile myoclonic epilepsy (JME). Valproate, the usual first line agent for JME, has chronic adverse effects, particularly for women of childbearing potential. Since JME requires lifetime treatment, chronic adverse effects of therapy are important consideration. METHODS We reviewed ...

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A Young Adult with Myoclonic Seizure

A 21-year-old man was referred to dermatology clinic for skin biopsy. He presented to neurology center with behavioral changes with cognition and memory disorders. He had two episodes of genealized tonic clonic seizure and series of myoclonc jerks in his limbs and face especially after awakening since several months ago. In neurological examination, he had mini mental score as 13; with so...

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ژورنال

عنوان ژورنال: Seizure

سال: 2012

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2012.08.008